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Updated: Aug 14, 2026

Retinal Detachment Model in Rodents by Subretinal Injection of Sodium Hyaluronate
Published on: September 11, 2013
Intravitreal gas injection diminishes hyaluronic acid
H Lincoff1, I Kreissig, J Horowitz
1Department of Ophthalmology, New York Hospital-Cornell Medical Center, New York, USA.
Objectives:
To determine if compression of the vitreous by an intraocular gas bubble diminishes the concentration of hyaluronic acid (NaHA).
Materials And Methods:
Eighteen albino rabbits had air, xenon or perfluoroethane (C2F6) injected into the vitreous to displace 12.5% to 90% of the vitreous volume. After the gas was absorbed, the vitreous was analyzed for NaHA by the Carbazole method (1, 13).
Results:
A 90% displacement diminished the NaHA concentration by 18.6%. Lesser displacements caused a lesser loss, but the differences are not significant.
Conclusion:
Intraocular gas injections, both large and small, reduce the concentration of NaHA and destabilize the vitreous structure.
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