Related Experiment Videos
[Granular cell tumor of the scrotum with high pseudoepitheliomatous hyperplasia]
M Medina Pérez1, I Valpuesta Fernández, J Valero Puerta
1Servicio de Anatomía Patológica, Hospital de la Merced, Osuna, Sevilla, España.
Objective:
To report a rare case of scrotal granular cell tumor.
Methods:
A 19-year-old man presented with a nodule on the scrotum, 2 cm in diameter. It had been present for months and was covered with ulcerated epidermis. The tumor was resected.
Results:
The histological study disclosed a neoplasm composed of polygonal cells with cytoplasmic granules and pseudoepitheliomatous hyperplasia of the overlying skin. Immunohistochemically, the cells showed a strong positivity for S100 protein and vimentin. The proliferation index (ki 67) was low in its cells, but high in the overlying hyperplasic epidermal cells.
Conclusions:
To our knowledge, this is the second case of scrotal granular cell tumor reported. The case described herein has the unique feature of severe overlying pseudoepitheliomatous hyperplasia. S100 positivity supports a neurogenic differentiation.