Evaluation of rapidly disintegrating tablets prepared by a direct compression method
Related Experiment Video
Updated: Oct 23, 2026

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
1Department of Pharmacy, Meijo University, Nagoya, Japan. d5971101@meijo-u.ac.jp
Abstract:
To make rapidly disintegrating tablets with sufficient mechanical integrity as well as a pleasant taste, microcrystalline cellulose (MCC), Tablettose (TT), and crosslinked sodium carboxymethyl cellulose (Ac-di-sol) or erythritol (ET) were formulated. Tablets were made by a direct compression method (I). Tablet properties such as porosity, tensile strength, and disintegration time were determined. The tensile strength and disintegration time were selected as response variables, tablet porosity and parameters representing the characteristics of formulation were selected as controlling factors, and their relation was determined by the polynomial regression method. Response surface plots and contour plots of tablet tensile strength and disintegration time were also constructed. The optimum combination of tablet porosity and formulation was obtained by superimposing the contour diagrams of tablet tensile strength and disintegration time. Rapidly disintegrating tablets with durable structure and desirable taste could be prepared within the obtained optimum region.
Related Concept Videos
In Vitro Drug Dissolution: Compendial Testing Models I
Factors Influencing Drug Absorption: Pharmaceutical Parameters
In Vitro Drug Dissolution: Compendial Testing Models II
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules
In Vitro Drug Dissolution: Alternative Methods
Drug Dissolution: Requirements and Profile Comparison
