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Updated: Aug 5, 2026
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Development and evaluation of rizatriptan benzoate orally disintegrating tablets for migraine treatment
Nevin Çelebi1,2, Emine Tuncay1,3
1Department of Pharmaceutical Technology, Faculty of Pharmacy, Gazi University, Ankara, Turkey.
Drug Development and Industrial Pharmacy
|August 3, 2026
Summary
Rizatriptan benzoate (RZT) orally disintegrating tablets (ODTs) were successfully developed for migraine treatment. Formulations using Ludiflash® and Pharmaburst™ exhibited optimal disintegration and dissolution profiles, comparable to commercial products.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
- Medicinal Chemistry
Background:
- Migraine is a prevalent neurological disorder impacting patient quality of life.
- Orally disintegrating tablets (ODTs) offer rapid onset of action and improved patient compliance for migraine management.
- Development of effective ODT formulations is crucial for enhancing therapeutic outcomes.
Purpose of the Study:
- To develop rizatriptan benzoate (RZT) ODTs using direct compression and super-disintegrants.
- To evaluate the performance of RZT ODTs against a commercial product (Maxalt®RPD).
- To characterize the physical and chemical properties of the developed ODTs.
Main Methods:
- Formulation of RZT ODTs utilizing super-disintegrants (Ludiflash®, Ludipress®, Pharmaburst™) via direct compression.
- In vitro assessment of disintegration time, dissolution rate, porosity, water absorption, and wetting time.
- Analysis of drug-excipient interactions using Differential Scanning Calorimetry (DSC) and X-ray Diffraction (X-RD).
Main Results:
- ODT formulations with Ludiflash® and Pharmaburst™ demonstrated favorable disintegration and dissolution characteristics.
- The developed ODTs exhibited high porosity and rapid water uptake.
- No significant interactions were observed between RZT and the selected excipients.
Conclusions:
- Successful development of RZT ODTs using direct compression and super-disintegrants.
- The developed ODTs show potential as an effective alternative for migraine treatment.
- Further studies may explore in vivo performance and patient acceptance.
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