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Cataplasm-based controlled drug delivery: development and optimization of a novel formulation
V Agarwal1, S K Singh, I K Reddy
1Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo 79106, USA.
Drug Development and Industrial Pharmacy
|April 29, 1999
Summary
This study optimized ibuprofen cataplasm formulation for enhanced drug release. Key variables like carbopol and glycerol were adjusted to maximize drug flux and minimize lag time, achieving significant in vitro release improvements.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Cataplasms offer a transdermal drug delivery route.
- Optimizing formulation variables is crucial for effective drug release.
Purpose of the Study:
- To investigate formulation variables for a novel plasterlike preparation (cataplasm).
- To optimize variables for maximum in vitro drug release and minimum lag time.
Main Methods:
- A face-centered cubic design was employed to study formulation variables.
- Ibuprofen was used as the model drug, with carbopol, glycerol, and indopol as key excipients.
- Franz's diffusion cells were used to assess in vitro drug diffusion across a cellulosic membrane.
Main Results:
- Optimization predicted a maximum flux of 97.22 mcg/cm2/hr.
- Optimal concentrations were identified as 2% w/w carbopol, 11.75% w/w glycerol, and 6% w/w indopol.
- An experimental cataplasm achieved a flux of 90.7 mcg/cm2/hr, validating the optimization model.
Conclusions:
- Formulation optimization significantly enhances in vitro drug release from cataplasms.
- The developed cataplasm formulation shows potential for effective transdermal drug delivery.