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New controlled-release ibuprofen tablets.

G F Palmieri1, D Lovato, S Martelli

  • 1Dipartimento di Scienze Chimiche, Università di Camerino, Italy.

Drug Development and Industrial Pharmacy
|April 29, 1999
PubMed
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New ibuprofen tablets offer rapid pain relief and sustained therapeutic effects. This dual-release formulation utilizes a blend of ibuprofen-starch granules and ibuprofen-Eudragit RS microspheres for single-dose convenience.

Area of Science:

  • Pharmaceutical Technology
  • Drug Delivery Systems
  • Materials Science

Background:

  • Conventional ibuprofen formulations may not provide optimal therapeutic profiles.
  • Achieving both rapid onset and prolonged drug release from a single dosage form presents a formulation challenge.

Purpose of the Study:

  • To develop and characterize a novel ibuprofen tablet with dual-release kinetics.
  • To enable rapid therapeutic effect and sustained drug release via a single oral administration.

Main Methods:

  • Formulation of two distinct ibuprofen-containing granules: ibuprofen-starch (fast release) and ibuprofen-Eudragit RS microspheres (slow, linear release).
  • Compression of specific mixtures of these two granule types into tablets.
  • Optimization of tablet hardness to achieve desired release profiles.

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Main Results:

  • Tablets successfully exhibited both very fast and slow, linear ibuprofen release kinetics.
  • The combination of ibuprofen-starch and ibuprofen-Eudragit RS microspheres allowed for dual-release characteristics.
  • Controlled compression and granulation were key to achieving the desired release profiles.

Conclusions:

  • A single ibuprofen tablet formulation capable of fast and sustained release was successfully developed.
  • This dual-release system offers a promising approach for improved patient compliance and therapeutic outcomes.
  • The formulation strategy highlights the potential of combining different release technologies within a single dosage form.