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Proximal-type epithelioid sarcoma in the pelvic soft tissues
1Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan.
Summary
Proximal-type epithelioid sarcoma is a rare pelvic tumor. Early diagnosis is crucial as it can metastasize quickly, impacting patient prognosis.
Area of Science:
- Oncology
- Pathology
Background:
- Epithelioid sarcoma is a rare soft tissue sarcoma.
- Proximal-type epithelioid sarcoma typically occurs in deeper soft tissues.
Observation:
- A case of proximal-type epithelioid sarcoma in a 46-year-old man's pelvic soft tissues is detailed.
- The tumor exhibited epithelioid and rhabdoid features with specific cellular morphology.
- Immunohistochemistry revealed positivity for cytokeratin CAM5.2, vimentin, EMA, and CD34.
Findings:
- The tumor displayed a complex growth pattern including cord-like and alveolar arrangements.
- Flow cytometry indicated diploid DNA content with a high S-phase fraction.
- Pelvic lymph-node metastasis was present at diagnosis.
Implications:
- This case highlights the importance of considering proximal-type epithelioid sarcoma in pelvic tumor differential diagnoses.
- The aggressive nature and rapid metastasis underscore the need for prompt recognition and management.
- Understanding the histological and immunophenotypical profile aids in accurate diagnosis.