[The pathogenetic mechanisms of paroxysmal trigeminal prosopalgias]

Clinical and experimental studies of formation of paroxysmal trigeminal pain are carried out in patients with typical trigeminal neuralgia (TN), TN with neuropathic disorders, TN concomitant with disseminated sclerosis, and symptomatic TN caused by vestibulo-cochlear neurinoma (VIII pair). Trigeminal, acoustic stem, and visual evoked potentials were recorded, electroencephalography (including mapping) and magnetic imaging were carried out. In experiments, bioelectric activity of the brain was recorded in rats with TN and neuropathy. Paroxysmal trigeminal prosopalgias are caused by various etiologic factors and involve mainly the sensory trigeminal radicles. Total systems' pathogenetic processes characteristic of this disease are described.