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Updated: Aug 19, 2026

Intracellular Refolding Assay
Published on: January 24, 2012
Molecular chaperones: How J domains turn on Hsp70s
1Département de Biochimie Médicale, CMU-Université de Genève, 1 rue Michel-Servet, 1211 Genève 4, Switzerland. William.Kelley@medecine.unige.ch
Abstract:
Molecular chaperones of the heat shock protein 70 (Hsp70) variety facilitate protein folding and assembly. They are assisted in this role by their Hsp40 partners, and recent studies have shed new light on how the 'J domains' of these 'cochaperones' activate substrate binding by Hsp70 molecules.
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