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Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits
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Diabetic versus nondiabetic limb-threatening ischemia: outcome of percutaneous iliac intervention

L D Spence1, G G Hartnell, G Reinking

  • 1Department of Radiological Sciences, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02218, USA.

AJR. American Journal of Roentgenology
|May 5, 1999
PubMed

Insights

Diabetic and nondiabetic patients showed similar outcomes after iliac angioplasty for limb-threatening ischemia. This endovascular procedure offers comparable limb salvage and patency rates, regardless of diabetic status.

Area of Science:

  • Vascular Surgery
  • Endovascular Interventions
  • Diabetic Complications

Background:

  • Limb-threatening ischemia poses significant risks for both diabetic and nondiabetic patients.
  • Iliac artery disease is a common cause of critical limb ischemia.
  • Understanding treatment outcomes in diabetic populations is crucial due to higher prevalence of vascular disease.

Purpose of the Study:

  • To compare the effectiveness of iliac angioplasty in patients with limb-threatening ischemia.
  • To evaluate outcomes, including patency and limb salvage, between diabetic and nondiabetic patients.

Main Methods:

  • Retrospective review of 91 patients undergoing iliac angioplasty for limb-threatening ischemia over 6 years.
  • Life table analysis and log-rank tests used to compare outcomes.
  • Stents were utilized for suboptimal angioplasty results.

Main Results:

  • Outcomes were comparable between diabetic (75% of patients) and nondiabetic groups.
  • Four-year primary iliac patency rates were 85% (diabetic) vs. 76% (nondiabetic).
  • Four-year limb salvage rates were 93% (diabetic) vs. 79% (nondiabetic), with no significant difference.

Conclusions:

  • Iliac angioplasty provides comparable outcomes for diabetic and nondiabetic patients with limb-threatening ischemia.
  • Current endovascular techniques and infrainguinal reconstruction are effective across both groups.
  • Limb salvage and arterial patency rates support iliac angioplasty as a viable treatment option regardless of diabetes.
Abstract

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