Related Experiment Video
Updated: Jul 26, 2026

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model
Published on: September 29, 2011
The error catastrophe hypothesis and aging
Abstract:
A theory of the propagation of errors in the system of enzymes translating genetic information into proteins developed earlier is extended to include errors at the transcription level. The theory is compared to other statistical theories. The properties are defined of the protein synthesizing machineries, especially those of the erroneous enzymes, which give catastrophe, stable self-replication containing errors, recovery from errors, etc. Experimental data are analyzed in light of the theory to determine the validity of the error catastrophe hypothesis of aging.
Related Concept Videos
Replicative Cell Senescence
The Effect of Aging on Tissues
Drug Dosing: Geriatric Patients
Cognitive Development During Adulthood
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Alzheimer Disease l: Introduction

