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Related Experiment Videos

Origin of periodic proteins

M Ycas

    Federation Proceedings
    |August 1, 1976
    PubMed
    Summary

    The origin of periodic proteins like collagen may stem from repetitive replication of small nucleic acid segments, leading to internal self-complementarity. This saltatory process offers an alternative to gradual amino acid replacement for explaining protein evolution.

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    Area of Science:

    • Biochemistry
    • Molecular Biology
    • Evolutionary Biology

    Background:

    • Certain proteins, such as collagen, exhibit approximately periodic amino acid sequences.
    • Nucleic acid templates for these proteins show significant internal self-complementarity.
    • Explaining the origin of periodic proteins via gradual amino acid substitution is challenging.

    Purpose of the Study:

    • To propose a novel mechanism for the saltatory origin of periodic proteins.
    • To explain the development of internal self-complementarity in nucleic acid templates.
    • To provide a plausible evolutionary pathway for proteins with repetitive structures.

    Main Methods:

    • Theoretical modeling of nucleic acid replication processes.
    • Analysis of sequence complementarity in DNA and RNA.
    • Comparative genomics to identify patterns in protein and nucleic acid sequences.

    Main Results:

    • A repetitive replication model for small nucleic acid segments is proposed.
    • This model explains the emergence of internal self-complementarity by incorporating sequences from both DNA strands.
    • The proposed mechanism is applicable to both DNA and RNA, potentially explaining structures like transfer RNA (tRNA).

    Conclusions:

    • The saltatory origin of periodic proteins through repetitive nucleic acid replication is a viable hypothesis.
    • Internal self-complementarity in nucleic acid templates arises naturally from this replication process.
    • This mechanism offers a parsimonious explanation for the evolution of proteins with repeating amino acid patterns.

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