Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Corticosteroid-resistant asthma: basic aspects].

D Jaffuel1, M Mathieu, P Chanez

  • 1INSERM U454, Hôpital Arnaud de Villeneuve, Montpellier.

Presse Medicale (Paris, France : 1983)
|May 6, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to 'Management of obstructive sleep apnea syndrome type 1 in children and adolescents - A French consensus' [Arch Pediatr (2023) 510-16].

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2024
Same author

SQ HDM Sublingual Immunotherapy Tablet for the Treatment of HDM Allergic Rhinitis and Asthma Improves Subjective Sleepiness and Insomnia: An Exploratory Analysis of the Real-life CARIOCA Study.

Journal of investigational allergology & clinical immunology·2023
Same author

Management of obstructive sleep apnea syndrome type 1 in children and adolescents - A French consensus.

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2023
Same author

[Telemonitoring in continuous positive airway pressure-treated patients with obstructive sleep apnoea syndrome: An algorithm proposal].

Revue des maladies respiratoires·2020
Same author

Effects of an individualized exercise training program on severity markers of obstructive sleep apnea syndrome: a randomised controlled trial.

Sleep medicine·2020
Same author

[Adaptive servo-ventilation after the SERVE-HF study: The swan song?].

Revue des maladies respiratoires·2016
Same journal

Predictive analytics and risk stratification models in internal medicine: from risk scores to real-time machine learning.

Presse medicale (Paris, France : 1983)·2026
Same journal

Artificial Intelligence in skin disease therapeutics: from drug discovery to personalized treatment pathways.

Presse medicale (Paris, France : 1983)·2026
Same journal

AI in clinical diagnostics in dermatology: applications, validation, and real-world use cases.

Presse medicale (Paris, France : 1983)·2026
Same journal

Artificial Intelligence in medical research and publishing: progress, risks, and future perspectives.

Presse medicale (Paris, France : 1983)·2026
Same journal

Ethical, legal, and regulatory challenges in AI-based healthcare tools.

Presse medicale (Paris, France : 1983)·2026
Same journal

Decision-making for clinicians.

Presse medicale (Paris, France : 1983)·2026
See all related articles

The definition of corticosteroid-resistant asthma lacks consensus, impacting treatment. Current definitions overlook clinical benefits, necessitating individualized patient care for better asthma management.

Area of Science:

  • Pulmonology
  • Pharmacology

Context:

  • The current definition of corticosteroid-resistant asthma relies on spirometry but lacks standardized criteria for diagnosis.
  • Significant patient populations, nearly half, are on long-term oral steroids, yet clinical benefits are often excluded from resistance definitions.
  • This ambiguity complicates the identification and management of patients with true corticosteroid resistance.

Purpose:

  • To highlight the limitations and controversies surrounding the current definition of corticosteroid-resistant asthma.
  • To discuss the complex pathogenesis involving pharmacokinetic and cellular anomalies.
  • To outline prerequisites for alternative therapies and emphasize the need for clinically evident resistance.

Summary:

  • The definition of corticosteroid-resistant asthma is debated, lacking consensus on diagnostic parameters like dose, duration, route, and FEV1 reversibility.

Related Experiment Videos

  • Pathogenesis involves complex anomalies in glucocorticoid pharmacokinetics, cytokine regulation, cell function, and transcription factors.
  • Therapeutic management is challenging, requiring confirmed asthma diagnosis, environmental control, compliance, and documented lack of clinical benefit from corticosteroids before considering alternative treatments.

    • Impact:

    • Clarifying the definition of corticosteroid resistance is crucial for accurate diagnosis and appropriate treatment selection.
    • Understanding the complex pathogenesis may lead to targeted therapies.
    • Establishing clear criteria for alternative treatments ensures patient safety and optimizes outcomes in difficult-to-treat asthma.