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[Propacetamol: from basic action to clinical utilization]
1Département d'anesthésie-douleur, centre hospitalier universitaire, Nîmes, France.
Objective:
To review pharmacology and therapeutic use of propacetamol, an injectable prodrug of acetaminophen (paracetamol).
Data Sources:
Extraction from the Medline database of French and English articles on pharmacology and clinical use of propacetamol.
Study Selection:
Articles providing new data into the mechanisms of the analgesic action of paracetamol. Selection of controlled studies (original articles and abstracts of oral communications on therapeutic trials with propacetamol as a single agent or part of balanced analgesia protocols). Case reports and letters to the editor were not considered in this analysis.
Data Extraction:
Clinical articles were selected for advantages and adverse effects of propacetamol. Articles dealing with mechanisms of action of propacetamol and paracetamol were selected for the more recent data, excluding those reporting outdated theories not confirmed or abandoned.
Data Synthesis And Conclusion:
Mechanisms of action of paracetamol differ from those of NSAIDs, giving account of a low risk of adverse renal, gastrointestinal and haematological effects. Thanks to their high therapeutic index, prescription of propacetamol and paracetamol is quite simple and safe. Main indications of both drugs are painful conditions, especially but not exclusively in the postoperative period, not requiring opioids and also in combination with other analgesic drug and/or techniques (balanced or multimodal analgesia). Because of cost, IV propacetamol is changed for oral paracetamol as soon as possible.