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Related Experiment Videos

Stimulant medications.

L L Greenhill1, J M Halperin, H Abikoff

  • 1Division of Child and Adolescent Psychiatry, New York State Psychiatric Institute, New York, NY 10032, USA. 73766.103@compuserve.com

Journal of the American Academy of Child and Adolescent Psychiatry
|May 7, 1999
PubMed
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Stimulant medications are effective and safe for treating children with attention-deficit/hyperactivity disorder (ADHD) in the short term. Longer-term studies suggest continued safe and effective use up to 24 months.

Area of Science:

  • Pediatric pharmacology
  • Neurodevelopmental disorders

Background:

  • Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children.
  • Stimulant medications are frequently prescribed for ADHD management.

Purpose of the Study:

  • To assess the short- and long-term safety and efficacy of stimulant medications for treating ADHD in children.

Main Methods:

  • A comprehensive literature search of randomized controlled trials and reviews was performed.
  • Data on adverse events, growth impacts, animal studies (tolerance, sensitization, neurotoxicity, tumorigenicity), and human dopamine transporter occupancy were analyzed.

Main Results:

  • Stimulant treatment demonstrates robust short-term efficacy and a favorable safety profile in children with ADHD.

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  • Limited long-term studies have not found conclusive evidence of harm with careful therapeutic use.
  • Conclusions:

    • Current evidence supports the efficacy and safety of stimulant medications for ADHD treatment in children for studies extending up to 24 months.