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Apolipoprotein E polymorphism in sheep.

K Tsunoda1, Y Yamamoto, Y Akiya

  • 1Department of Legal Medicine, Showa University School of Medicine, Tokyo, Japan.

Biochemical Genetics
|May 7, 1999
PubMed
Summary
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Genetic polymorphism in sheep apolipoprotein E (APO E) was analyzed in European and Asian breeds. Seven codominant alleles (APOE1-APOE7) control APO E phenotypes, with distinct allele frequencies observed between the two sheep groups.

Area of Science:

  • Animal Genetics
  • Biochemistry
  • Immunology

Background:

  • Apolipoprotein E (APO E) plays a crucial role in lipid metabolism.
  • Understanding APO E genetic polymorphism is vital for livestock breeding and health.
  • Previous studies have focused on human APO E, with limited data on sheep.

Purpose of the Study:

  • To investigate the genetic polymorphism of apolipoprotein E (APO E) in diverse sheep populations.
  • To identify and characterize APO E variants and their allele frequencies in European and Asian sheep.
  • To determine the inheritance pattern of APO E phenotypes in sheep.

Main Methods:

  • Isoelectric focusing (IEF) of desialylated plasma proteins.
  • Immunoblotting using anti-human APO E antibody for APO E detection.

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  • Analysis of family and population data to establish genetic control.

    • Main Results:

    • Twenty APO E phenotypes were identified, resulting from combinations of seven detected variants (E1-E7).
    • The APO E phenotypes are controlled by seven codominant alleles (APOE1-APOE7) at a single autosomal locus.
    • Common alleles APOE4, APOE5, and APOE7 showed varying frequencies between European and Asian sheep groups.

    Conclusions:

    • The genetic polymorphism of sheep APO E is complex, involving multiple codominant alleles.
    • Significant differences in APO E allele frequencies exist between European and Asian sheep populations.
    • This study provides a foundation for further research into the functional and evolutionary significance of sheep APO E variants.