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Mortality rates after cataract extraction.

D R Meddings1, S A Marion, M L Barer

  • 1Department of Health Care and Epidemiology, University of British Columbia, Vancouver, Canada.

Epidemiology (Cambridge, Mass.)
|May 7, 1999
PubMed
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Senile cataracts may indicate widespread tissue aging. This study found that the link between cataracts and mortality risk persisted even with increased cataract surgery rates, suggesting aging is a common factor.

Area of Science:

  • Gerontology
  • Ophthalmology
  • Epidemiology

Background:

  • Senile cataract is proposed as a potential indicator of systemic tissue aging.
  • The association between cataracts and generalized aging requires further investigation, particularly concerning the impact of surgical interventions.

Purpose of the Study:

  • To test the hypothesis that senile cataract is a marker of generalized tissue aging.
  • To determine if the association between cataracts and mortality diminishes with increased cataract surgery utilization.

Main Methods:

  • Population-based linked health data from British Columbia were analyzed.
  • Mortality rates of individuals aged 50-95 undergoing cataract surgery in 1985 and 1989 were compared to age-matched controls not undergoing surgery.
  • Cox regression and additive risk models were employed to assess mortality risk.

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Main Results:

  • For the 1985 cohort, hazard ratios for mortality were elevated in younger age groups (e.g., 3.2 for males 50-54.9 years), decreasing with age.
  • Additive risk models showed excess mortality that was less dependent on age.
  • Similar findings were observed in the 1989 cohort, indicating a consistent association between cataracts and aging regardless of surgery rates.

Conclusions:

  • The association between senile cataracts and generalized aging appears robust.
  • Increased cataract surgery rates did not diminish the observed link between cataracts and mortality risk.
  • Cataracts may indeed serve as a marker for broader systemic aging processes.