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Related Experiment Videos

Linear IgA disease associated with lymphocytic colitis.

O Swensson1, E Stüber, T Nickel

  • 1Departments of Dermatology and Internal Medicine, University of Kiel, Schittenhelmstr., 24105 Kiel, Germany.

The British Journal of Dermatology
|May 8, 1999
PubMed
Summary

Linear IgA disease (LAD) can present with chronic diarrhea and skin blistering. This case highlights a rare co-occurrence with lymphocytic colitis, responding well to treatment.

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Area of Science:

  • Dermatology
  • Gastroenterology
  • Immunology

Background:

  • Linear IgA disease (LAD) is a rare autoimmune blistering skin disorder.
  • Gastrointestinal symptoms, though uncommon, can occur in LAD patients.
  • Lymphocytic colitis is an inflammatory condition of the colon.

Observation:

  • A 66-year-old woman presented with bullous skin eruption and chronic watery diarrhea.
  • Skin biopsy revealed subepidermal blistering with linear IgA deposits.
  • Colon histology showed features consistent with lymphocytic colitis.

Findings:

  • Diagnosis of linear IgA disease (LAD) and lymphocytic colitis were established.
  • Treatment with methylprednisolone and dapsone resolved skin lesions and improved diarrhea.

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  • This case represents a rare co-occurrence of LAD and lymphocytic colitis.

    • Implications:

    • The co-occurrence of LAD and lymphocytic colitis is rarely reported.
    • Further research is needed to determine if a pathogenic link exists between LAD and lymphocytic colitis.
    • This case expands the understanding of potential gastrointestinal manifestations in LAD.