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[Vaccinations in dermatology].

M Sticherling1

  • 1Psoriasiszentrum, Deutsches Zentrum Immuntherapie, Hautklinik Universitätsklinikum Erlangen, Ulmenweg 18, 91045, Erlangen, Deutschland. Michael.sticherling@uk-erlangen.de.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|January 21, 2021
PubMed
Summary
This summary is machine-generated.

Vaccinations are safe and effective, with rare adverse reactions outweighed by protection from natural infections. Special considerations are needed for individuals with chronic skin conditions on immunosuppressants.

Keywords:
Adverse reactionsAtopic dermatitisIntolerance reactionsLichen planusPsoriasis

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Area of Science:

  • Immunology
  • Dermatology
  • Public Health

Background:

  • Vaccinations are critical prophylactic medical interventions.
  • Regulatory approval involves clinical studies and registry data.
  • Adverse reactions must be weighed against natural infection risks and vaccine benefits.

Purpose of the Study:

  • To review adverse reactions to vaccinations, focusing on dermatological conditions.
  • To provide guidance on vaccinating individuals with chronic dermatoses, particularly those on immunosuppressive therapy.

Main Methods:

  • Literature review of vaccination adverse events and dermatological reactions.
  • Analysis of clinical guidelines for vaccinating immunocompromised patients.

Main Results:

  • Intolerance reactions to vaccines are rare and often suspected rather than proven.
  • Specific dermatoses (psoriasis, atopic dermatitis, lichen planus) and allergic reactions can occur.
  • Inactivated vaccines are permissible during immunosuppressive therapy, though potentially less immunogenic; live vaccines should be avoided.

Conclusions:

  • Individuals with chronic dermatoses on immunosuppressive/immunomodulatory therapy should receive recommended vaccinations.
  • Vaccinations should be deferred during acute skin manifestations.
  • Immunosuppressive comedication necessitates careful consideration for vaccine timing and type.