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Experimental His-bundle pacing: histopathological and electrophysiological examination
S Amitani1, K Miyahara, H Sohara
1Division of Cardiology, Shinkyo Hospital, Kagoshima, Japan.
Pacing and Clinical Electrophysiology : PACE
|May 11, 1999
Summary
His-bundle pacing offers physiological ventricular contraction. A study in beagles demonstrated that a screw-in lead provided stable fixation and no adverse histological effects, suggesting feasibility for permanent clinical use.
Area of Science:
- Cardiology
- Electrophysiology
- Medical Devices
Background:
- His-bundle pacing provides more physiological ventricular contraction than right ventricular apical pacing.
- Long-term His-bundle pacing faces challenges with lead fixation and stability.
Purpose of the Study:
- To evaluate the feasibility of permanent His-bundle pacing using a screw-in lead.
- To assess lead fixation, stability, and histopathological changes in the conduction system over two months.
Main Methods:
- Six adult beagles were implanted with screw-in leads in the His-bundle region.
- Pacing parameters and histopathological changes were monitored for two months.
Main Results:
- Satisfactory lead fixation was achieved with the screw-in lead.
- No histological influence on the conduction system was observed.
- Pacing thresholds, R wave amplitude, impedance, and slew rate were recorded at implantation and after two months.
Conclusions:
- Permanent His-bundle pacing using a screw-in lead is feasible.
- The screw-in lead demonstrated adequate fixation and stability without causing histological damage.