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Alterations in intracellular calcium during sepsis
1Indian Institute of Chemical Biology, Calcutta.
Indian Journal of Physiology and Pharmacology
|May 11, 1999
Summary
Sepsis alters intracellular calcium regulation, particularly in skeletal muscle, impacting organ function. Calcium-channel blockers may help mitigate these harmful effects during septic injury.
Area of Science:
- Biochemistry
- Physiology
- Microbiology
Background:
- Tissue injury and infection significantly disrupt intracellular calcium ion regulation.
- Sepsis, a life-threatening condition, involves complex cellular calcium disturbances.
- Gram-negative bacteria are frequently implicated in human abdominal sepsis.
Purpose of the Study:
- To investigate alterations in intracellular calcium regulation during septic models.
- To examine the functional consequences of altered calcium flux in major organs, especially skeletal muscle.
- To evaluate potential therapeutic interventions for septic calcium dysregulation.
Main Methods:
- Utilized short-term and long-term septic models with gram-negative bacteria.
- Assessed calcium flux using 45Ca exchange, 19F NMR spectroscopy, and calcium-fluorescence probes.
- Monitored functional disturbances in major organs and skeletal muscle.
Main Results:
- Significant alterations in intracellular calcium ion regulation were observed in septic models.
- Changes in calcium flux and functional disturbances occurred in major organs, notably skeletal muscle.
- Calcium-channel blockers demonstrated an ability to attenuate increased calcium flux.
Conclusions:
- Sepsis profoundly affects cellular calcium homeostasis, leading to organ dysfunction.
- Targeting calcium flux with blockers may offer a therapeutic strategy against septic injury.
- Anti-cytokine therapies could potentially prevent tissue damage in sepsis.