Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pancuronium bromide: an indirect sympathomimetic agent.

J S Domenech, R C Garcia, J M Sastain

    British Journal of Anaesthesia
    |December 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    An update on the role of miRNA-155 in pathogenic microbial infections.

    Microbes and infection·2015
    Same author

    Environmental factors, familial aggregation and heritability of total cholesterol, low density lipoprotein-cholesterol and high density lipoprotein-cholesterol in a Brazilian population assisted by the Family Doctor Program.

    Public health·2011
    Same author

    Prevalence of leptospirosis in dairy cattle from small rural production units in Toluca Valley, State of Mexico.

    Annals of the New York Academy of Sciences·2009
    Same author

    The effect of IL-5 treatment on the stimulation-induced phosphorylation of proteins in blood eosinophils.

    Cytokine·2004
    Same author

    Eosinophil cationic protein is stored in, but not produced by, peripheral blood neutrophils.

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2002
    Same author

    The mechanisms of serum-treated zymosan (STZ)-induced oxidative metabolism by human eosinophils and the effects of IL-5 priming.

    Allergy·2001

    Pancuronium increases blood pressure in dogs by releasing noradrenaline from nerve endings. This effect can be restored by noradrenaline even after tachyphylaxis, suggesting a specific mechanism of action.

    Area of Science:

    • Pharmacology
    • Cardiovascular Physiology
    • Neuropharmacology

    Background:

    • Pancuronium is a neuromuscular blocking agent.
    • Its cardiovascular effects are not fully understood.
    • Previous studies suggest potential interactions with the sympathetic nervous system.

    Purpose of the Study:

    • To investigate the mechanism of pancuronium-induced pressor responses in dogs.
    • To determine if pancuronium releases noradrenaline.
    • To explore the role of the sympathetic nervous system in pancuronium's cardiovascular effects.

    Main Methods:

    • Administered pancuronium (0.2 mg/kg) to dogs and monitored cardiovascular parameters (left ventricular systolic pressure, systemic arterial pressure, central venous pressure).
    • Investigated tachyphylaxis to pancuronium and its restoration.

    Related Experiment Videos

  • Utilized noradrenaline infusions and sympathetic blocking agents (desipramine, guanethidine, reserpine) to probe the underlying mechanisms.

    • Main Results:

    • Pancuronium increased left ventricular systolic and systemic arterial pressures, with diminishing responses upon repeated dosing (tachyphylaxis).
    • Pressor response to pancuronium was restored by intravenous noradrenaline infusion after tachyphylaxis.
    • Sympathetic blocking agents (desipramine, guanethidine, reserpine) inhibited the restoration of the pressor response by noradrenaline.

    Conclusions:

    • Findings support the hypothesis that pancuronium induces a pressor response by triggering noradrenaline release from postganglionic nerve endings.
    • The sympathetic nervous system plays a crucial role in mediating pancuronium's cardiovascular effects.
    • Pancuronium's action involves interaction with noradrenergic neurotransmission.