[Effect of antithrombin III on anticoagulating system function in animals intravenously injected with tissue...

In experiments with rats, antithrombin III (a natural inhibitor of fibrinolysis) was shown to decrease the activation of the anticoagulation system either in prophylactic administration or during the development of thrombogenesis, caused by intravenous administration of tissue thromboplastin. The phenomenon led to the maintaining of the more high content of fibrinogen in blood of experimental animals, to the shortening of the thrombin time and to the increase in content of alpha2-macroglobulin and alpha1-antitrypsin (in-hibitors of fibrinolysis) as compard with control animals, administered with the only thrombolastin. Effect of antithrombin III depended on periods of administration of the prearation and on injection of tissue thromboplastin.