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Polyagglutinability associated with the cad antigen.

A Gerbal, M Lopez, C Maslet

    Haematologia
    |January 1, 1976
    PubMed
    Summary
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    The Cad and Sda red blood cell antigens are distinct, despite Cad cells showing strong Sda reactivity. An anti-Cad antibody in human sera, not anti-Sda, causes Cad red cell polyagglutinability.

    Area of Science:

    • Immunology
    • Transfusion Medicine
    • Blood Group Serology

    Background:

    • The Cad and Sda antigens are known red blood cell surface markers.
    • Previous studies suggested a potential identity or close relationship between Cad and Sda specificities.

    Purpose of the Study:

    • To investigate the precise antigenic relationship between Cad and Sda.
    • To determine if Cad and Sda antigens are identical or distinct entities.

    Main Methods:

    • Testing various anti-Cad and anti-Sda reagents.
    • Utilizing a panel of Cad-positive red blood cells for analysis.

    Main Results:

    • Cad red blood cells consistently exhibited strong reactivity with anti-Sda reagents.

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  • Despite strong Sda reactivity, Cad and Sda antigen specificities were determined to be non-identical.
  • Polyagglutinability observed in Cad red cells was attributed to the presence of an anti-Cad antibody in all human sera, independent of anti-Sda.

    • Conclusions:

    • Cad and Sda represent distinct red blood cell antigen specificities.
    • The polyagglutinability of Cad red cells is associated with a naturally occurring anti-Cad antibody.
    • This finding clarifies the serological differences between Cad and Sda antigens.