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Radiculomyelitis following acute haemorrhagic conjunctivitis
Brain : a Journal of Neurology
|December 1, 1976
Summary
Acute hemorrhagic conjunctivitis (AHC) can cause a serious neurological condition called radiculomyelitis. This condition leads to paralysis and muscle atrophy, particularly in adults, highlighting the neurovirulent properties of the AHC virus.
Area of Science:
- Neurology
- Virology
- Infectious Diseases
Background:
- Acute hemorrhagic conjunctivitis (AHC) is a newly reported disease.
- Neurological complications following AHC were investigated in a series of patients.
Observation:
- Thirty-three adult patients (ages 21-55) developed radiculomyelitis 5-37 days after AHC onset.
- Key neurological signs included radicular pain and acute flaccid paralysis, often asymmetrical and affecting proximal lower limbs.
- Cerebrospinal fluid analysis revealed pleocytosis and elevated protein levels; antibody titers confirmed AHC virus infection in most patients.
Findings:
- Motor paralysis was the most prominent feature, with significant muscle atrophy and potential for permanent incapacitation in severe cases.
- The clinical presentation and prognosis resembled poliomyelitis, suggesting anterior horn cell involvement.
- The study confirmed an etiological link between the AHC virus and this neurological syndrome.
Implications:
- This neurological syndrome is caused by the neurovirulent properties of the AHC virus.
- Understanding this link is crucial for differentiating it from polio and Guillain-Barré syndrome.
- The findings emphasize the importance of recognizing AHC as a potential cause of neurological disease.
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