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Recurrent Pseudomonas infection associated with neutrophil dysfunction
Scandinavian Journal of Infectious Diseases
|January 1, 1978
Summary
This study details an elderly male with recurrent Pseudomonas aeruginosa infections and chronic otitis media. His polymorphonuclear leukocytes (PMNs) showed impaired function, suggesting acquired immune defects in adults.
Area of Science:
- Immunology
- Infectious Diseases
- Geriatrics
Background:
- Recurrent infections in elderly individuals warrant thorough investigation.
- Pseudomonas aeruginosa sepsis and chronic otitis media present significant clinical challenges.
Observation:
- A 72-year-old male experienced multiple episodes of Pseudomonas aeruginosa sepsis and chronic otitis media.
- In vitro analysis of the patient's polymorphonuclear leukocytes (PMNs) demonstrated severely impaired chemotaxis and intracellular killing of bacteria.
Findings:
- Markedly depressed chemiluminescence production and nitroblue tetrazolium dye reduction in PMNs were observed.
- These results indicate a profound, seemingly acquired, defect in PMN function.
Implications:
- Adults with recurrent infections may have undiagnosed, acquired defects in polymorphonuclear leukocyte function.
- Further evaluation of such patients could reveal similar immune deficiencies.
- This case highlights the importance of detailed immunological assessment in the elderly with persistent infections.