Related Experiment Videos
Synthesis of cancer peptide antigen-lipid A analog conjugates for synthetic vaccines
K Ikeda1, K Miyajima, Y Maruyama
1School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Chemical & Pharmaceutical Bulletin
|May 13, 1999
Abstract:
Conjugates 6 and 7 of cancer peptide antigen with N-tetradecanoyl L-serine-beta-alanine-containing D-glucosamine derivative structurally related to lipid A as an immunoadjuvant were synthesized for the development of totally synthetic vaccines against cancers. The mitogenic activities of compounds 6 and 7 were stronger than that of lipid A analog 3.