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Inotropic and chronotropic effects of antiarrhythmic agents onisolated blood-perfused canine ventricular tissue
Recent Advances in Studies on Cardiac Structure and Metabolism
|May 26, 1976
Abstract:
In the isolated blood-perfused canine ventricular tissue, antiarrhythmic agents could be classified as having: 1) positive chronotropic and inotropic effects (procainamide), 2) negative chronotropic but positive inotropic effects (quinidine), and 3) negative chronotropic and inotropic effects (lidocaine, ajmaline, diphenylhydantoin, and propranolol).