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Calcium paradox: changes in high-energy phosphate compounds of isolated perfused rat hearts
Recent Advances in Studies on Cardiac Structure and Metabolism
|May 26, 1976
Abstract:
When isolated rat hearts are perfused with Ca2+-containing medium, after a brief Ca2+-free period, irreversible cell damage occurs (calcium paradox). This phenomenon is concomitant with a rapid consumption of myocardial high-energy phosphate stores, prior to the appearance of these compounds in the effluent perfusion medium. A possible mechanism for the origin of myocardial necrosis, caused by intracellular Ca2+ overload, is discussed.