Related Experiment Video
Updated: Aug 9, 2026

Laminectomy and Spinal Cord Window Implantation in the Mouse
Published on: October 23, 2019
Bupivacaine versus lidocaine for third molar surgery: a double-blind, randomized, crossover study
G F Bouloux1, A Punnia-Moorthy
1Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Sydney, Australia. gboulou@emory.edu
Purpose:
The aim of this study was to compare the clinical use of bupivacaine to lidocaine in third molar surgery.
Patients And Methods:
Twenty-three subjects underwent surgical removal of their third molars in two separate procedures. Bupivacaine was used for the third molars on one side, whereas lidocaine was used on the other side. Pain experience, analgesic consumption, cardiovascular response, blood concentrations, and systemic toxicity were evaluated.
Results:
Bupivacaine significantly reduced the postoperative pain experience only at the 8-hour period (P < .05). No difference in analgesic requirements or cardiovascular responses was observed with the two local anesthetics. The mean blood concentrations of both agents were considerably lower than their respective toxic threshold concentrations.
Conclusion:
The results of this study do not show a difference in a variety of parameters, other than postoperative pain experience, when bupivacaine and lidocaine are compared in a standardized oral surgery procedure.
Related Concept Videos
Local Anesthetics: Common Agents and Their Applications
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia
Local Anesthetics: Clinical Application as Spinal Anesthesia
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
