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Absolute bioavailability of moxifloxacin
C Ballow1, J Lettieri, V Agarwal
1State University of New York at Buffalo School of Pharmacy, USA.
Clinical Therapeutics
|May 13, 1999
Summary
Moxifloxacin, an 8-methoxy-fluoroquinolone antibiotic, demonstrated high absolute bioavailability (91.8%) following oral administration in healthy males. This suggests effective absorption for potential oral therapy.
Area of Science:
- Pharmacology
- Clinical Pharmacy
- Infectious Diseases
Background:
- Moxifloxacin is an investigational 8-methoxy-fluoroquinolone antibiotic.
- It exhibits broad-spectrum activity against gram-positive and gram-negative bacteria.
Purpose of the Study:
- To determine the absolute bioavailability of moxifloxacin.
- To compare pharmacokinetic characteristics of oral versus intravenous moxifloxacin.
Main Methods:
- Open-label, randomized, crossover study design.
- 10 healthy male volunteers received a single 100-mg dose orally and intravenously (60-minute infusion).
- Pharmacokinetic parameters including peak serum concentration and area under the concentration-time curve were analyzed.
Main Results:
- Geometric mean absolute bioavailability of oral moxifloxacin was 91.8%.
- Peak serum concentrations were 1.15 mg/L (oral) and 1.34 mg/L (IV).
- Mean renal clearance was 2.3 L/h, indicating minimal active tubular secretion.
Conclusions:
- Single oral moxifloxacin doses are extensively absorbed in healthy young men.
- Further studies in patients are needed to confirm IV to oral dose conversion viability.