Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Coactivator and corepressor complexes in nuclear receptor function.

L Xu1, C K Glass, M G Rosenfeld

  • 1Howard Hughes Medical Institute, Biomedical Sciences PhD Program, University of California at San Diego, La Jolla, California 92093-0648, USA.

Current Opinion in Genetics & Development
|May 14, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of natural genetic variation on enhancer selection and function.

Nature·2013
Same author

Macrophage scavenger receptors and atherosclerosis.

Trends in cardiovascular medicine·2011
Same author

Use of mouse models to evaluate roles of nuclear receptors and their ligands in the pathogenesis and treatment of atherosclerosis.

Current drug targets·2008
Same author

Differential recruitment of the coactivator proteins CREB-binding protein and steroid receptor coactivator-1 to peroxisome proliferator-activated receptor gamma/9-cis-retinoic acid receptor heterodimers by ligands present in oxidized low-density lipoprotein.

The Journal of endocrinology·2003
Same author

Regulation of macrophage gene expression by the peroxisome proliferator-activated receptor-gamma.

Hormone research·2001
Same author

New roles for PPARs in cholesterol homeostasis.

Trends in pharmacological sciences·2001
Same journal

Decoding bipotency: a transient regulatory state bridging totipotency and lineage commitment.

Current opinion in genetics & development·2026
Same journal

Functional immunogenomics and deep clinical phenotyping to resolve the challenges of heterogeneity in mental disorders.

Current opinion in genetics & development·2026
Same journal

Temporal trajectories underlying adult neuronal diversity.

Current opinion in genetics & development·2026
Same journal

Transcription regulation of cell fate plasticity - from embryonic development to tissue regeneration.

Current opinion in genetics & development·2026
Same journal

Shared molecular and cellular programs during regeneration of glandular epithelia.

Current opinion in genetics & development·2026
Same journal

Lineage tracing in human cortical development.

Current opinion in genetics & development·2026
See all related articles

Nuclear hormone receptors switch from repression to activation upon ligand binding. This involves displacing histone deacetylase (HDAC) complexes and recruiting histone acetyltransferase (HAT) complexes for transcriptional control.

Area of Science:

  • Molecular Biology
  • Genetics
  • Endocrinology

Background:

  • Nuclear hormone receptors are key transcription factors regulating gene expression.
  • Ligand binding induces conformational changes in nuclear receptors, impacting transcriptional activity.

Purpose of the Study:

  • To elucidate the general mechanism of ligand-dependent transcriptional activation by nuclear hormone receptors.
  • To investigate the role of chromatin-modifying complexes in nuclear receptor function.

Main Methods:

  • Analysis of retinoic acid and thyroid hormone receptors.
  • Investigating the exchange of protein complexes upon ligand binding.

Main Results:

  • Ligand binding causes the displacement of histone deacetylase (HDAC)-containing complexes from nuclear receptors.

Related Experiment Videos

  • Histone acetyltransferase (HAT)-containing complexes are recruited to nuclear receptors after ligand binding.

    • Conclusions:

    • Ligand-dependent recruitment of chromatin-remodeling activity is a general mechanism for nuclear receptor activation.
    • Nuclear receptors transition from a repressive to an active transcriptional state through chromatin modification.