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Telomeres and telomerase: broad effects on cell growth
1Department of Chemistry and Biochemistry, N146 Beadle, University of Nebraska, Lincoln, Nebraska 68588, USA. cmp@biocomp.unl.edu
Current Opinion in Genetics & Development
|May 14, 1999
Abstract:
During the past year, major advances have been made in understanding the link between telomerase expression and cell immortality. Studies of yeast telomeres have revealed an unexpected role for the non-homologous end-joining machinery in telomere maintenance and have provided the first definitive evidence that telomeres play a critical role in meiosis. Identification of new telomere proteins has led to a better understanding of vertebrate telomere structure and function.