Related Experiment Videos
Growing up on the streets: why B-cell development differs from T-cell development
S E Townsend1, B C Weintraub, C C Goodnow
1Australian Cancer Research Foundation Genetics Laboratory, Medical Genome Centre, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.
Immunology Today
|May 14, 1999
Abstract:
B-cell development differs significantly from T-cell development in that negative selection of autoreactive B cells can occur in the same microenvironment in which productive immune responses begin. Here, Sarah Townsend and colleagues discuss how this 'growing up on the streets' might provide a mechanism that fills holes in the B-cell repertoire, much as major histocompatibility complex polymorphism fills holes in the T-cell repertoire.