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Coated dosage forms for colon-specific drug delivery
1Department of Pharmaceutical Technology, Heinrich Heine University, Universitätsstrasse 1, 40225 Düsseldorf, Germany.
Pharmaceutical Science & Technology Today
|May 14, 1999
Summary
This review explores colon-specific drug delivery systems using advanced coating materials. It details pH, time, enzyme, and pressure-controlled release mechanisms for targeted oral dosage forms.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
- Polymer Science
Background:
- Colon-specific drug delivery is crucial for treating colonic diseases and improving oral drug bioavailability.
- Conventional oral dosage forms often fail to reach the colon intact due to premature drug release in the upper gastrointestinal tract.
Purpose of the Study:
- To provide a comprehensive overview of coated dosage forms designed for colon specificity.
- To discuss various polymer-based coating strategies enabling targeted drug release in the colon.
Main Methods:
- Review of scientific literature on colon-specific drug delivery systems.
- Analysis of different release mechanisms: pH-controlled, time-controlled, enzyme-controlled, and pressure-controlled release.
- Examination of polymer properties and their application in coating formulations.
Main Results:
- Multiple coating materials and release mechanisms are available for achieving colon specificity.
- pH-dependent polymers, swelling/erosion polymers, enzyme-degradable polymers, and pressure-sensitive polymers are key technologies.
- These technologies leverage physiological differences between the small and large intestines for targeted delivery.
Conclusions:
- Coated dosage forms offer effective strategies for colon-specific drug delivery.
- The choice of coating material and release mechanism depends on the specific therapeutic goal and physiological conditions.
- Further development in polymer science will continue to enhance colon-targeted drug delivery systems.
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