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Related Experiment Videos

Coated dosage forms for colon-specific drug delivery.

Leopold1

  • 1Department of Pharmaceutical Technology, Heinrich Heine University, Universitätsstrasse 1, 40225 Düsseldorf, Germany.

Pharmaceutical Science & Technology Today
|May 14, 1999
PubMed
Summary

This review explores colon-specific drug delivery systems using advanced coating materials. It details pH, time, enzyme, and pressure-controlled release mechanisms for targeted oral dosage forms.

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Area of Science:

  • Pharmaceutical Technology
  • Drug Delivery Systems
  • Polymer Science

Background:

  • Colon-specific drug delivery is crucial for treating colonic diseases and improving oral drug bioavailability.
  • Conventional oral dosage forms often fail to reach the colon intact due to premature drug release in the upper gastrointestinal tract.

Purpose of the Study:

  • To provide a comprehensive overview of coated dosage forms designed for colon specificity.
  • To discuss various polymer-based coating strategies enabling targeted drug release in the colon.

Main Methods:

  • Review of scientific literature on colon-specific drug delivery systems.
  • Analysis of different release mechanisms: pH-controlled, time-controlled, enzyme-controlled, and pressure-controlled release.
  • Examination of polymer properties and their application in coating formulations.

Main Results:

  • Multiple coating materials and release mechanisms are available for achieving colon specificity.
  • pH-dependent polymers, swelling/erosion polymers, enzyme-degradable polymers, and pressure-sensitive polymers are key technologies.
  • These technologies leverage physiological differences between the small and large intestines for targeted delivery.

Conclusions:

  • Coated dosage forms offer effective strategies for colon-specific drug delivery.
  • The choice of coating material and release mechanism depends on the specific therapeutic goal and physiological conditions.
  • Further development in polymer science will continue to enhance colon-targeted drug delivery systems.

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