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Updated: Oct 21, 2026

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery
Published on: May 16, 2021
Dynamic diversity and small-molecule evolution: a new paradigm for ligand identification
1Department of Chemistry, University of Rochester, Rochester, NY 14627, USA. klekota@miller1.chem.rochester.edu
Abstract:
A longstanding goal of organic, medicinal and bioorganic chemists has been the discovery of efficient methods for designing or identifying biologically active compounds. Recently, several groups have reported using the directed evolution of combinatorial libraries as a new method of identifying compounds capable of binding tightly to a target molecule. Although significant development remains to be done, the initial results suggest that dynamic diversity and associated selection methods will prove to be valuable additions to the drug-discovery process.
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