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[Preliminary studies on the relationship between vitamin D receptor gene polymorphism and osteoporosis in Chinese
Abstract:
The relationship between vitamin D receptor (VDR) gene polymorphism and osteoporosis were studied. The polymerase chain reaction-restriction fragment length polymorphism was used to detect VDR genotype in 162 healthy postmenopausal women and 17 patients with osteoporosis. The genotype frequencies of VDR were calculated later with Hardy-Weinberg equilibrium formula. The results showed that in controls, the bb, Bb, and BB genotype accounted for 91.36%, 8.64%, and 0% respectively. Of those patients with osteoporosis, they were 82.35%, 17.65%, and 0% respectively. The results suggested that there was no association between VDR genotype and osteoporosis noticed.
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