[Detection of HGV RNA in sera from patients with fulminant hepatitis in Shenyang]

HGV RNA was detected by Rt-nested PCR in sera from 49 patients with fulminant hepatitis. The results showed: a) HGV RNA positive rate was 16.3% (8/49) in patients with fulminant hepatitis including 4 subjects with HBV coinfection, 1 subject with HCV coinfection, 2 subjects with HBV and HCV coinfection and 1 subject with HGV infection alone. b) mortality in patients with fulminant hepatitis with HGV infection was 75% (6/8), suggesting that: a) both infection with HGV alone and superinfections of other types of hepatitis virus can result in fulminant hepatitis, b) clinical manifestations of fulminant hepatitis with HGV infection may appear to be more severe and with higher mortality.