Related Experiment Video
Updated: Jun 26, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
[Association between levels of plasma lipid profile with apolipoprotein B gene polymorphism in 93 children]
Objective:
To study the relationship between levels of plasma lipid profile and variation of apolipoprotein (Apo) B gene.
Methods:
The relationship between frequency of polymorphism genotype of Apo B gene Xba I locus and levels of plasma lipid profile was studied in 93 children aged eight to eleven years.
Results:
The frequency of dominant X- allele (common allele) in Xba I locus was 0.967 in the children and that of uncommon X+ allele 0.033. Average levels of plasma total cholesterol (TC) and low density lipoprotein cholesterol (LDL-ch) in children with X- X+ genotype (4.59 and 2.98 mmol/L, respectively) were significantly higher than those with X-X- genotype (3.84 and 2.32 mmol/L, respectively). Levels of TC and/or LDL-ch in 4 of 6, cases of X-X+ genotype exceeded their the 90th percentile, indicating association between X+ allele and high plasma cholesterol level.
Conclusion:
To certain extent, there is association between polymorphism of Xba I locus of Apo B gene and levels of plasma lipid profile in children, which may be a genetic marker for abnormal level of plasma lipid profile during childhood.
Related Concept Videos
Pedigree Analysis
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Pharmacogenomics: Identification of New Drug Targets
Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...

