Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Drug-induced immunotoxicity.

P M Dansette1, E Bonierbale, C Minoletti

  • 1Université Ren Descartes, CNRS URA 400, Paris, France.

European Journal of Drug Metabolism and Pharmacokinetics
|May 14, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Will we ever be able to accurately predict solubility?

Scientific data·2024
Same author

Cytochrome P450 2U1, a very peculiar member of the human P450s family.

Cellular and molecular life sciences : CMLS·2017
Same author

CYP3A5 is the major cytochrome P450 3A expressed in human colon and colonic cell lines.

Environmental toxicology and pharmacology·2011
Same author

Brief historical overview and recent progress on cytochromes P450: adaptation of aerobic organisms to their chemical environment and new mechanisms of prodrug bioactivation.

Annales pharmaceutiques francaises·2011
Same author

The end product of transglutaminase crosslinking: simultaneous quantitation of [Nepsilon-(gamma-glutamyl) lysine] and lysine by HPLC-MS3.

Analytical biochemistry·2008
Same author

Beclin 1 mRNA strongly correlates with Bcl-XLmRNA expression in human hepatocellular carcinoma.

Cancer investigation·2007
Same journal

Population Pharmacokinetic Modeling Study of Glibenclamide in Chinese Healthy Volunteers.

European journal of drug metabolism and pharmacokinetics·2026
Same journal

A Relative Bioavailability Study of Vepdegestrant Tablets in Healthy Adult Participants.

European journal of drug metabolism and pharmacokinetics·2026
Same journal

Population Pharmacokinetics of Amikacin in Non-Neonatal Pediatric Patients: A Scoping Review.

European journal of drug metabolism and pharmacokinetics·2026
Same journal

Investigating the Impact of Calcium Channel Blockers on the Pharmacokinetics of Lapatinib: Possible Role of Cytochrome P450 Enzymes and P-glycoprotein Efflux Transporters.

European journal of drug metabolism and pharmacokinetics·2026
Same journal

Clinical Relevance of the 516 G>T Polymorphism in CYP2B6 and Its Effects on Efavirenz Concentrations in Patients with HIV and Tuberculosis: A Meta-analysis.

European journal of drug metabolism and pharmacokinetics·2026
Same journal

Toxicity-Tailored Thresholds of Delayed Methotrexate Elimination in Non-Hodgkin Lymphoma: A Population-Based Approach to Therapy Optimization.

European journal of drug metabolism and pharmacokinetics·2026
See all related articles

Immune-related drug responses can cause liver damage through immunoallergic hepatitis. This review explores mechanisms where drugs form neoantigens, triggering immune responses and potential liver cell destruction.

Area of Science:

  • Hepatology
  • Immunotoxicology
  • Drug Metabolism

Background:

  • Immune-related drug responses are a common cause of idiosyncratic toxicity, frequently targeting the liver.
  • Drug-induced hepatitis is categorized into acute and immunoallergic types, with the latter involving adverse immune responses against the liver.

Purpose of the Study:

  • To review the mechanisms of immunoallergic drug-induced hepatitis.
  • To highlight recent progress in understanding how drugs trigger immune responses leading to liver damage.

Main Methods:

  • Review of clinical features of immunoallergic hepatitis (low frequency, dose independence, immune manifestations, delayed onset, shortened rechallenge delay, autoantibodies).
  • Examination of drug examples (halothane, tienilic acid, dihydralazine, anticonvulsants) to illustrate disease mechanisms.

Related Experiment Videos

Main Results:

  • Postulated mechanisms involve drug metabolism into reactive metabolites that bind to enzymes, forming neoantigens.
  • Neoantigens trigger immune responses, including antibody production against native/modified proteins.
  • Rechallenge increases neoantigen production, potentially leading to antibody-induced cytolysis.

Conclusions:

  • Drug-induced liver injury involves neoantigen formation and subsequent immune system activation.
  • Toxicity depends on neoantigen characteristics, quantity, and individual immune factors.
  • Further research is needed to elucidate precise mechanisms and identify at-risk drugs, potentially utilizing animal models.