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Updated: Jul 10, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Blastic mantle cell leukemia: a previously undescribed form.

C H Dunphy¹, J C Hancock, J J Rodriguez

¹Department of Pathology, St. Louis University Health Sciences Center, Missouri, USA.

Journal of Clinical Laboratory Analysis

|May 14, 1999

Summary

Mantle cell leukemia, a rare blood cancer, typically involves small lymphocytes. This case report describes a unique blastic morphologic variant, previously undocumented in the leukemic phase of mantle cell lymphoma.

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Area of Science:

Hematology
Oncology
Pathology

Background:

Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin lymphoma.
The leukemic phase, termed mantle cell leukemia (MCL), is defined by specific lymphocyte counts and morphology.
While blastic variants of MCL exist, a blastic morphologic variant of MCL has not been previously described.

Observation:

A 74-year-old male presented with splenic rupture and an elevated white blood cell (WBC) count.
Peripheral blood examination revealed lymphocytes with blastic morphology.
Diagnostic workup included flow cytometric immunophenotyping and cytomorphology.

Findings:

The case presented a rare blastic morphologic variant of mantle cell leukemia.
Diagnosis was confirmed through immunophenotyping and cytomorphology, identifying the blastic nature in the leukemic phase.
This represents the first documented instance of a blastic morphologic variant in the leukemic phase of MCL.

Implications:

This finding expands the known morphologic spectrum of mantle cell leukemia.
It highlights the importance of considering blastic morphology in the differential diagnosis of leukemic B-cell lymphomas.
Further research may elucidate the clinical behavior and treatment implications of this rare variant.