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Targeted Labeling of Neurons in a Specific Functional Micro-domain of the Neocortex by Combining Intrinsic Signal and Two-photon Imaging
Published on: December 12, 2012
Separate signals for target selection and movement specification in the superior colliculus
1Howard Hughes Medical Institute and Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Science (New York, N.Y.)
|May 15, 1999
Summary
The brain uses a selection process to choose saccade targets. Some superior colliculus neurons aid target selection, while others prepare the eye movement after selection.
Area of Science:
- Neuroscience
- Oculomotor research
- Visual processing
Background:
- The brain must select saccade targets from multiple options.
- Superior colliculus (SC) neurons show activity before saccades, but their role is debated.
Purpose of the Study:
- To investigate the role of SC neurons in saccade target selection.
- To differentiate between pre- and post-selection functions of SC neurons.
Main Methods:
- Recording SC neuron activity in monkeys performing a motion-direction-based saccade task.
Main Results:
- Some SC neurons exhibited direction-selective visual responses, indicating a role in target selection.
- Other SC neurons appeared to be involved in post-selection saccade parameter specification.
Conclusions:
- SC neurons play distinct roles in both selecting saccade targets and preparing subsequent eye movements.
- Evidence suggests a dual function for SC neurons in the oculomotor system.
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