Related Experiment Videos
High-grade prostatic intraepithelial neoplasia in dogs
1Cancer Biology Laboratory, School of Veterinary Medicine, Purdue University, West Lafayette, Ind. 47907, USA.
European Urology
|May 15, 1999
Summary
Canine high-grade intraepithelial neoplasia (HGPIN) closely resembles human HGPIN, suggesting dogs may serve as a model for prostate cancer research. This finding supports using HGPIN in dogs to test potential cancer-preventing drugs.
Area of Science:
- Comparative oncology
- Veterinary pathology
- Prostate cancer research
Background:
- Dogs are unique in spontaneously developing high-grade intraepithelial neoplasia (HGPIN) and invasive carcinoma of the prostate.
- Canine HGPIN exhibits significant morphological and molecular similarities to human HGPIN.
Purpose of the Study:
- To describe HGPIN in the canine prostate.
- To investigate the potential of dogs as a model for human prostate cancer.
- To explore the use of canine HGPIN as a biomarker for chemopreventive agent screening.
Main Methods:
- Morphological comparison of canine and human HGPIN.
- Analysis of basal layer disruption, proliferative index, and microvessel density.
- Epidemiological study of HGPIN prevalence in pet dogs.
Main Results:
- Canine HGPIN is morphologically similar to human HGPIN, including basal layer disruption, proliferative index, and microvessel density.
- HGPIN is an intermediate step between benign epithelium and invasive carcinoma.
- HGPIN is present in 55% of elderly, intact pet dogs.
Conclusions:
- Canine HGPIN is a relevant model for human prostate cancer.
- Early prostate carcinogenesis events occur frequently in pet dogs.
- Canine HGPIN can serve as a surrogate biomarker for prostate cancer chemoprevention studies.