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Aspirin intolerance in patients with chronic sinusitis
J Gosepath1, F Hoffmann, D Schäfer
1Department of Otolaryngology, University of Mainz, School of Medicine, Mainz, Germany. Jan.Gosepath@t-online.de
Summary
Aspirin intolerance is linked to recurrent chronic sinusitis after surgery. Eicosanoid levels in blood cells can identify this intolerance, suggesting tolerance induction may prevent symptom recurrence.
Area of Science:
- Immunology
- Otolaryngology
- Biochemistry
Background:
- Aspirin intolerance frequently causes chronic rhinosinusitis symptom recurrence post-surgery.
- Nasal polyposis, often recurrent, is common in these patients, alongside asthma or allergies.
Purpose of the Study:
- To assess acetylsalicylic acid intolerance in chronic sinusitis patients.
- To correlate clinical findings with in vitro eicosanoid levels.
- To explore methods for reducing recurrent rhinosinusitis.
Main Methods:
- Tested 84 chronic sinusitis patients for acetylsalicylic acid intolerance.
- Analyzed peptido-leukotriene and prostaglandin E2 levels in isolated blood cells.
- Compared eicosanoid levels between aspirin-intolerant patients and healthy controls.
Main Results:
- Aspirin intolerance identified in 68% of patients.
- Elevated basal peptido-leukotrienes and reduced prostaglandin E2 in intolerant patients.
- Strong correlation found between clinical symptoms and in vitro eicosanoid levels.
Conclusions:
- In vitro eicosanoid analysis effectively identifies aspirin intolerance in chronic sinusitis.
- Inducing aspirin tolerance may reduce the risk of recurrent rhinosinusitis.
- Clinical symptomatology strongly correlates with eicosanoid profiles.