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Published on: January 23, 2017
Risk factors for hearing loss from meningitis in children: the Children's Hospital experience
A L Woolley1, K A Kirk, A M Neumann
1Department of Surgery, Children's Hospital, The University of Alabama at Birmingham, 35233, USA.
Insights
Meningitis can cause hearing loss in 13.7% of children, with some cases being progressive. Key risk factors for hearing loss include increased intracranial pressure and male sex.
Area of Science:
- Pediatric Neurology
- Audiology
- Infectious Diseases
Background:
- Meningitis is a serious infection that can lead to severe complications in children.
- Hearing loss is a known, but not fully understood, sequela of pediatric meningitis.
Purpose of the Study:
- To identify significant risk factors for hearing loss in children with meningitis.
- To determine the incidence of hearing loss post-meningitis.
- To quantify the rate of progressive or fluctuating hearing loss.
Main Methods:
- Retrospective analysis of 432 children diagnosed with meningitis between 1985 and 1995.
- Utilized multiple logistic regression modeling to identify risk factors.
- Examined variables including CT scan findings, CSF glucose, and clinical signs.
Main Results:
- Hearing loss developed in 13.7% (59/432) of children with meningitis.
- Of those with hearing loss, 78% had stable sensorineural hearing loss, while 22% experienced progressive or fluctuating loss.
- Significant predictors for hearing loss included increased intracranial pressure (OR=2.3), male sex (OR=1.9), low CSF glucose (OR=0.58), Streptococcus pneumoniae (OR=2.1), and nuchal rigidity (OR=1.9).
Conclusions:
- Hearing loss is a significant complication of pediatric meningitis, affecting 13.7% of cases.
- Progressive or fluctuating hearing loss occurred in 22% of affected children.
- Increased intracranial pressure, male sex, low CSF glucose, S. pneumoniae infection, and nuchal rigidity are key predictors of hearing loss in children with meningitis.
Objectives:
To identify statistically significant risk factors for hearing loss in children with meningitis, determine the overall incidence of hearing loss in a large group of children with confirmed meningitis, and quantify the percentage of children with progressive or fluctuating hearing loss after meningitis.
Design:
Retrospective analysis.
Patients And Other Participants:
Four hundred thirty-two children admitted to the Children's Hospital, Birmingham, Ala, from January 1, 1985, to December 31, 1995, with the diagnosis of meningitis.
Results:
Of 432 children with meningitis, 59 (13.7%) had the development of hearing loss. Of these 59 children, 46 (78.0%) had stable sensorineural hearing loss and 13 (22.0%) had either progressive or fluctuating hearing loss. Of the variables examined using multiple logistic regression backward-elimination modeling, only 5 appeared to be significantly associated with the development of hearing loss: computed tomographic scan evidence of increased intracranial pressure (estimated odds ratio [OR] = 2.3), male sex (OR= 1.9), the common logarithm of glucose levels in the cerebrospinal fluid (OR = 0.58), Streptococcus pneumoniae as the causative organism (OR= 2.1), and the presence of nuchal rigidity (OR = 1.9). In the children with progressive hearing loss, the time for progression varied from 3 months to 4 years before hearing stabilized.
Conclusions:
In this study of children diagnosed as having meningitis, hearing loss developed in 59 (13.7%). Forty-six (78.0%) of these children with hearing loss had stable auditory thresholds over time, and 13 (22.0%) exhibited deterioration or fluctuation of acuity over time. Evidence of increased intracranial pressure by computed tomographic scan, male sex, low glucose levels in the patients' cerebrospinal fluid, S pneumoniae as the causative organism, and the presence of nuchal rigidity appear to be significant predictors for future hearing loss.
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