[Changes in liver dehydrogenase activity in rats with Unden poisoning]

Changes in LDH, SDH, MDH and G-6-PDH activity in the liver of white male rats are studied within 2, 4, 8, 15, 30, 60 and 90 days of treatment with 1/10 and 1/50 LD50 and after 15 days recovery period following the 90-day-long treatment. The animals are divided up into three groups as follows: group one--treated with 1/10 LD50, group two--with 1/50 LD50, and a control group treated with vegetable oil solvent at the respective days. The findings show that changes in enzyme activity are comparatively one-way in terms of duration of the treatment. In the early days of the experiment, a reliable increase is noted followed by a normalization of the values and reliable reduction. At ninety days, and after the recovery period is over, the activities of all five enzymes do not differ from those in the control groups. The most clearly outlined changes are recorded in SDH, and the slightest--in MDH. The analysis of the picture obtained shows that in all instances it is a matter of reversible changes.