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Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis
1Department of Molecular Genetics, University of Texas Southwestern Medical Centre, Dallas 75235, USA. horton06@utsw.swmed.edu
Current Opinion in Lipidology
|May 18, 1999
Abstract:
A family of transcription factors designated sterol regulatory element-binding proteins (SREBPs) mediates the previously described end-product feedback regulation of cholesterol biosynthesis. In addition, SREBPs are emerging as important regulators of fatty acid synthesis. The current review focuses on the in-vivo regulation of SREBPs in liver and the coordinate regulation of SREBP-activated target genes.