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Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
Published on: January 21, 2018
Determination of hypercoagulable state in acute bronchospasm
H B Pandit1, C R Spillert, R D Shih
1Department of Surgery, UMDNJ-New Jersey Medical School, Newark, USA.
The Journal of the American Osteopathic Association
|May 18, 1999
Summary
Acute asthma and COPD attacks show hypercoagulability. A novel whole blood clotting test reveals differences between patients requiring hospitalization and those discharged, aiding in assessing coagulation status.
Area of Science:
- Hematology
- Pulmonary Medicine
- Clinical Coagulation
Background:
- Hypercoagulability in acute asthma is debated.
- Existing tests neglect cellular procoagulant activity.
- A comprehensive coagulation assessment is needed.
Purpose of the Study:
- To evaluate hypercoagulability in acute asthma and COPD.
- To utilize a whole blood clotting assay for comprehensive coagulation monitoring.
- To differentiate coagulation status in patients with varying severity of acute bronchospasm.
Main Methods:
- A modified recalcification time test using whole blood was employed.
- Blood samples from 12 patients with acute exacerbations (asthma/COPD) and 12 healthy controls were analyzed.
- Comparison of coagulation status between patient groups and controls.
Main Results:
- Patients with acute bronchospasm demonstrated a relative hypercoagulable state.
- The modified recalcification time test identified differences between patients needing hospital admission versus emergency department discharge.
- This assay accounts for both cellular and chemical procoagulant factors.
Conclusions:
- The modified recalcification time test is a valuable tool for assessing hypercoagulability in acute respiratory conditions.
- Coagulation differences exist based on the severity of acute bronchospasm.
- This assay provides a more complete picture of coagulation than traditional methods.
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