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Nasal toxicity of cocaine: a hypercoagulable effect?
1Department of Otolaryngology, University of Medicine and Dentistry of New Jersey-Newark, USA.
Journal of the National Medical Association
|May 9, 2000
Summary
Cocaine use does not appear to cause a hypercoagulable state. This study found no evidence that cocaine enhances blood clotting or tissue factor release, suggesting other factors cause nasal septum damage.
Area of Science:
- Toxicology
- Hematology
- Otolaryngology
Background:
- Nasal insufflation of cocaine is linked to nasal mucosa injury and septal perforation.
- Cocaine-induced vasoconstriction and ischemia are proposed mechanisms for this damage.
Purpose of the Study:
- To investigate if cocaine induces a hypercoagulable state.
- To determine if cocaine exacerbates nasal septal damage through coagulation changes.
Main Methods:
- Utilized Modified Recalcification Time (MRT) to assess overall coagulation.
- Examined the effects of cocaine on platelet function and monocyte-released tissue factor.
Main Results:
- No association was found between cocaine and enhanced platelet function.
- Cocaine did not significantly increase monocyte-released tissue factor.
- The overall coagulation process remained unaffected by cocaine addition.
Conclusions:
- Cocaine does not induce a hypercoagulable state.
- The study does not support cocaine-induced hypercoagulability as a factor in nasal septal ischemic changes.
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